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目的 :研究白细胞介素 6(IL 6)在增殖性玻璃体视网膜病变 (PVR)玻璃体中的表达水平 ,分析IL 6在PVR中的作用。方法 :对 3 7例增殖性玻璃体视网膜病变及 1 2例正常对照玻璃体IL 6进行定量测定 ,其中视网膜脱离PVR 2 2例 ,外伤性PVR 1 5例。IL 6的测定采用双抗夹心法 (ELISA)。结果 :3 7例PVR玻璃体IL 6水平为 2 64 87± 1 3 6 4 1 pg/ml,其中 2 2例视网膜脱离并发PVR者玻璃体IL 6水平为 2 61 4 2± 1 3 1 2 7pg/ml,外伤性PVR者玻璃体IL 6水平为 2 97 97± 1 4 1 53 pg/ml。正常对照玻璃体IL 6水平为 3 5 69± 2 0 64 pg/ml。PVR玻璃体IL 6水平显著高于正常对照组 (P <0 0 1 )。IL 6水平在PVRC、D级最高。结论 :白细胞介素 6(IL 6)在PVR中呈上行性表达 ,参与PVR的发生发展。IL 6主要在PVR中晚期发挥作用。
Objective: To investigate the expression of interleukin 6 (IL 6) in the vitreous of proliferative vitreoretinopathy (PVR) and to analyze the role of IL 6 in PVR. Methods: 37 cases of proliferative vitreoretinopathy and 12 cases of normal control vitreous IL 6 were quantitatively determined. Among them, 2 cases were retinal detachment from PVR and 15 cases were traumatic PVR. IL-6 was measured by double-antibody sandwich enzyme-linked immunosorbent assay (ELISA). Results: The level of IL-6 in 3 PVR vitreous was 2 64 87 ± 1 3 6 4 1 pg / ml. The level of vitreoretinal IL-2 in 2 2 cases with retinal detachment complicated with PVR was 2 61 4 2 ± 1 3 1 27 pg / ml , And the level of vitreous IL 6 in traumatic PVR was 2 97 97 ± 1 41 53 pg / ml. Normal control vitreous IL 6 levels were 3569 ± 2064 pg / ml. PVR vitreous IL 6 levels were significantly higher than the normal control group (P <0.01). IL 6 level in PVRC, D highest level. CONCLUSION: Interleukin 6 (IL 6) is up-regulated in PVR and is involved in the development of PVR. IL 6 mainly plays a role in the late stage of PVR.