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目的:调查我院矫形骨科关节置换患者预防应激性溃疡用药现状,探讨髋膝置换患者预防消化道溃疡出血的必要性.方法:调阅我院2017年9月出院的髋膝置换病例,统计患者的年龄,性别,合并内科基础疾病,相关检验指标、预防应激性溃疡药物及围手术期止疼和抗凝药物使用情况.结果:共收集109例,其中髋关节置换40例,膝关节置换69例,患者年龄中位数为63岁,非甾体镇痛抗炎药物(NSAIDs)使用率为98. 16% ,术后预防深静脉血栓药物使用率为95. 4% ,预防应激性溃疡药物使用率为67. 9% ,所有患者住院期间均未出现消化道出血.结论: 髋膝置换手术患者绝大多数为老年人,膝关节置换的患者年龄更高,而髋关节置换手术时间更长出血更多,围手术期普遍使用非甾体抗炎药物和预防深静脉血栓药物.目前该类人群是否常规需要预防应激性溃疡尚无定论,但联合使用阿司匹林及NSAIDs,是明确需要预防的危险因素.其他高危因素,以及预防用药的必要性,有待进行更大规模的调研.“,”Objective: To investigate the current situation of stress ulcer prevention in patients with orthopedic joint replacement in our hospital and explore the necessity of preventing bleeding of peptic ulcer in patients with hip/knee replacement. Methods: The ca-ses of hip/knee replacement discharged from our hospital in September 2017 were retrospectively analyzed. The age and gender of the patients were analyzed. The underlying medical conditions, the related laboratory indices and the uses of stress ulcer prevention drugs, analgesic and anticoagulation drugs were statistically analyzed. Results: A total of 109 cases were collected including 40 cases of hip replacement and 69 cases of knee replacement. The median of age was 63. The use rate of non-steroidal analgesic drugs was 98. 16% , that of deep venous thrombosis prevention drugs was 95. 4% , and that of stress ulcer prevention drugs was 67. 9% . No patient suffered from gastrointestinal bleeding. Conclusion: The majority of patients undergoing hip /knee replacement are the elderly, and the knee replacement patients are older with more operation duration and more bleeding during the hip replacement. Nonsteroidal anti-inflamma-tory drugs and the drugs for preventing deep venous thrombosis are widely used during perioperative period. At present, it is still uncer-tain whether the population needs regular prevention of stress ulcers. However, the combination of aspirin and NSAID is a risk factor. The other high-risk factors, as well as the necessity of prevention medication, still need to be investigated in a larger scale.