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目的探讨改良超长降调节方案在既往体外受精-胚胎移植失败的卵巢低反应患者中的应用效果。方法回顾性分析本中心58例连续两周期行体外受精-胚胎移植术的卵巢低反应患者,其中第一周期采用拮抗剂方案,第二周期采用改良超长方案。自身对照比较两组临床及实验室结果。结果第二周期获得了38.2%的临床妊娠率,两组Gn启动剂量、HCG日E2、LH及P值、HCG日子宫内膜厚度、获卵数、移植胚胎数比较无统计学差异(P>0.05),可移植胚胎数、冷冻胚胎数第二周期均较第一周期高,但无统计学差异(P>0.05);Gn天数、优质胚胎率、周期取消率第二周期组较第一周期组高,均有统计学差异(P<0.05)。结论对于既往采用拮抗剂方案失败的卵巢低反应患者,再次行体外受精-胚胎移植可尝试采用改良超长降调节方案。
Objective To investigate the effect of modified super-long-down regulation in patients with ovarian failure who had failed in vitro fertilization-embryo transfer. Methods A retrospective analysis of 58 patients with two-cycle in vitro fertilization-embryo transfer in patients with ovarian hyporesponsiveness, the first cycle of the antagonist program, the second cycle using the modified long program. Comparison of their own control two clinical and laboratory results. Results The clinical pregnancy rate was 38.2% in the second cycle. There was no significant difference between the two groups in the Gn activation dose, the E2, LH and P values on the HCG day, the endometrial thickness on the HCG day, the number of oocytes retrieved and the number of embryos transferred (P> 0.05), the number of transferable embryos and the number of frozen embryos in the second cycle were higher than those in the first cycle, but there was no significant difference (P> 0.05). The number of Gn days, There were significant differences between two groups (P <0.05). Conclusions For patients with ovarian failure who have previously failed the antagonist regimen, an IVF-ET regimen may be used again.