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目的探讨子宫内膜异位症(EMs)对体外受精-胚胎移植(IVF-ET)妊娠结局的影响。方法 155个周期EMs患者(A组,EMs组)以及同期309周期输卵管因素患者(B组,对照组)行IVF-ET,比较年龄、不孕年限、降调时间、Gn使用天数、Gn总量、HCG日子宫内膜厚度、HCG日E2值、获卵数、2PN率、卵裂率、优胚率、移植胚胎数、种植率、临床妊娠率、流产率并分析。结果内异症组Gn使用天数、获卵数、移植胚胎数显著低于对照组(P<0.01),其他指标两组无差异(P>0.05)。EMs组临床妊娠率较对照组有下降趋势[(40.65%(63/155)vs 42.72%(132/309))(P>0.05)、流产率较对照组有上升趋势[17.46%(11/63)vs 15.15%(20/132)](P>0.05)。结论 EMs患者卵巢储备功能下降,获卵数和可移植胚胎数显著下降,Gn使用天数、妊娠率有下降趋势,流产率有增加趋势。
Objective To investigate the effect of endometriosis (EMs) on the pregnancy outcome of in vitro fertilization-embryo transfer (IVF-ET). Methods IVF-ET was performed in patients with 155 cycles of EMs (group A, EMs) and patients with 309 cycles of tubal disease (group B, control) during the same period. The age, length of time of infertility, , Endometrial thickness on HCG day, E2 value on HCG day, number of oocytes retrieved, 2PN rate, cleavage rate, excellent embryo rate, embryo transfer number, implantation rate, clinical pregnancy rate and abortion rate were analyzed. Results The number of days of Gn, the number of oocytes retrieved and the number of embryos transferred in endometriosis group were significantly lower than those in control group (P <0.01). There was no significant difference in other indexes between the two groups (P> 0.05). The clinical pregnancy rate of EMs group was lower than that of the control group (40.65% vs 42.72% (132/309), P <0.05), and the abortion rate was higher than that of the control group (17.46%, 11/63 ) vs 15.15% (20/132)] (P> 0.05). Conclusions The ovarian reserve decreased, the number of oocytes retrieved and the number of transplanted embryos decreased significantly in EMs patients. The number of Gn days was decreased, the pregnancy rate decreased and the abortion rate increased.