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应用Power PlexFusion 5色荧光标记复合扩增系统,对605名贵州省汉族无关个体22个常染色体STR基因座遗传多态性进行调查。结果 22个STR基因座共观察到260个等位基因,945种基因型,各基因座基因型分布均符合Hardy-Weinberg平衡定律(P>0.05)。22个基因座遗传学参数值范围分别为:H值0.625~0.929,DP值0.804~0.985,PE值0.322~0.855,PIC值0.57~0.91,累计非父排除概率为0.999 999 999,累计个人识别率为1-1.301 4×10-26。22个STR基因座在贵州汉族人群中具有良好的遗传多态性,具有较高的法医学应用价值。
The genetic polymorphism of 22 autosomal STR loci in 605 unrelated Han individuals of Guizhou province was investigated by using Power Plex F Fusion 5-color fluorescent labeling multiplex amplification system. Results A total of 260 alleles and 945 genotypes were observed in 22 STR loci. The distribution of genotypes in each locus was in accordance with Hardy-Weinberg equilibrium (P> 0.05). The genetic parameters of 22 loci ranged from 0.625 to 0.929, from 0.804 to 0.985 for DP, from 0.322 to 0.855 for PE, from 0.57 to 0.91 for PIC, and from 0.999 to 999,999 for the cumulative non-parent, with a cumulative personal recognition rate 1-1.301 4 × 10-26.22 STR loci in Guizhou Han population has a good genetic polymorphism, with high forensic value.