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目的观察士的宁敏感的甘氨酸受体与七氟烷遗忘作用的关系。方法建立小鼠腹腔注射七氟烷遗忘模型,用跳台、避暗实验,观察不同剂量士的宁(0.05,0.10,0.15μg)侧脑室注射对小鼠跳台实验跳下潜伏期(SDL)、避暗实验步入潜伏期(STL)以及跳台和避暗实验错误(电击)次数的影响。结果与生理盐水组相比,士的宁对小鼠的SDL、STL和错误次数均无明显影响;七氟烷可明显减少小鼠的SDL和STL,增加错误次数(P<0.05)。士的宁可明显延长七氟烷所致记忆障碍小鼠的SDL、STL,减少错误次数(P<0.05)。结论士的宁敏感的甘氨酸受体介导了七氟烷的遗忘作用。
Objective To observe the relationship between strychnine-sensitive glycine receptors and the amnesia of sevoflurane. Methods The model of forgetfulness of sevoflurane was established by intraperitoneal injection of sevoflurane in mice. The experiment of jumping off and avoiding darkness was conducted. The effects of different doses of strychnine (0.05, 0.10 and 0.15 μg) Experimental ramp-in latency (STL), and the number of jumps and avoidance of experimental errors (shocks). Results Compared with the saline group, strychnine had no significant effect on the SDL, STL and the number of errors in mice. Sevoflurane significantly reduced the SDL and STL, and increased the number of errors (P <0.05). Strychnine would rather prolong the SDL and STL of sevoflurane-induced memory deficit mice, and reduce the number of errors (P <0.05). Conclusion Strychnine-sensitive glycine receptors mediate the amnesia of sevoflurane.