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目的:探讨Nrf2(Nuclear factor E2 p45-related factor2)在食管鳞癌组织中的表达及其与临床病理学特征的关系。方法:采用免疫组化SP法检测Nrf2在32例食管鳞癌,30例癌旁组织,21个阳性淋巴结和24个阴性淋巴结组织中的表达。结果:Nrf2阳性表达主要定位于细胞核中,在食管鳞癌中的阳性表达率为78.13%,显著高于癌旁组织(13.33%),淋巴结癌转移阳性组织中的表达率(66.67%)也显著高于淋巴结癌转移阴性组织中的表达水平(20.83%),均具有统计学意义(P<0.05)。Nrf2的阳性表达随淋巴结的转移度的增加而表达增加(P<0.05),但在不同年龄、性别、TNM分期、肿瘤分化程度及不同部位之间差异无统计学意义。结论:Nrf2在食管鳞癌中高表达,表达的高低与淋巴结转移与否及转移度有关。
Objective: To investigate the expression of nuclear factor E2 p45-related factor 2 (Nrf2) in esophageal squamous cell carcinoma and its relationship with clinicopathological features. Methods: Immunohistochemical SP method was used to detect the expression of Nrf2 in 32 cases of esophageal squamous cell carcinoma, 30 cases of adjacent tissues, 21 cases of positive lymph nodes and 24 cases of negative lymph nodes. Results: The positive expression of Nrf2 mainly localized in the nucleus and the positive expression rate in esophageal squamous cell carcinoma was 78.13%, significantly higher than that in paracancerous tissues (13.33%). The positive expression rate of Nrf2 in metastatic lymph node tissues was also significantly higher than that in paracancerous tissues (66.67%) Which was significantly higher than that in lymph node negative metastasis (20.83%) (P <0.05). The positive expression of Nrf2 increased with the degree of lymph node metastasis (P <0.05), but there was no significant difference in different age, gender, TNM stage, tumor differentiation and different sites. Conclusion: Nrf2 is overexpressed in esophageal squamous cell carcinoma, and the expression of Nrf2 is related to the metastasis of lymph nodes or not.