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通过抑制 gp1 2 0 - CD4结合来阻止人类免疫缺陷病毒 ( HIV)穿入 ,对预防 HIV感染是有潜在价值的策略。作者通过设计和合成不同长短和构象的 CD4 /共受体肽免疫原来探讨其主动免疫的可行性。 首先从能与 gp1 2 0结合的 CD4 /共受体复合物中能被单克隆抗体 ( m Ab) B4识别的
Prevention of human immunodeficiency virus (HIV) penetration by inhibiting gp120-CD4 binding is a potential strategy for preventing HIV infection. The authors explore the feasibility of their active immunization by designing and synthesizing CD4 / co-receptor peptide immunogens of different lengths and conformations. First, it can be recognized by the monoclonal antibody (m Ab) B4 in the CD4 / co-receptor complex that can bind to gp1020