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目的 研究川芎嗪（ｌｉｇｕｓｔｒａｚｉｎｅ，Ｌｉｇ） 对脑梗塞的保护作用。方法 大鼠脑梗塞模型采用右侧颈总动脉和右侧大脑中动脉的结扎，脑梗塞重量用ＮＢＴ 染色法测定。小鼠双侧颈总动脉结扎４ ｈ 后，取脑测丙二醛（ ＭＤＡ）、一氧化氮（ＮＯ）含量。血小板聚集用Ｂｏｒｎ 法测定。结果 Ｌｉｇ １０ ，２０，４０ ｍｇ·ｋｇ－ １ｉｖ 可显著改善大鼠异常神经症状和抑制ＡＬＰ活性的下降；Ｌｉｇ 可显著降低小鼠缺血脑组织ＮＯ 和ＭＤＡ 含量；Ｌｉｇ（２００，４００ ，８００ ｍｇ·Ｌ－１） 可显著抑制ＡＤＰ致血小板的聚集。结论 Ｌｉｇ 对脑梗塞有保护作用，此作用可能与抑制血小板聚集有关
Objective To study the protective effect of ligustrazine (Lig) on cerebral infarction. Methods The cerebral infarction model in rats was ligated with the right common carotid artery and the right middle cerebral artery. The weight of cerebral infarction was measured by NBT staining. After the bilateral common carotid artery was ligated for 4 h, the brains were measured for malondialdehyde (MDA) and nitric oxide (NO). Platelet aggregation was measured by the Born method. Results Lig 10, 20, 40 mg·kg - 1 iv significantly improved the abnormal neurological symptoms and inhibited the decrease of ALP activity; Lig significantly reduced the NO and MDA contents in the ischemic brain; Lig (200,400 ,800 mg L-1) significantly inhibits ADP-induced platelet aggregation. Conclusion Lig has a protective effect on cerebral infarction. This effect may be related to the inhibition of platelet aggregation.