本文报道多西环素引起急性严重颅内高压2例,其中发生永久视力缺损1例。例1,女,2 1岁。非洲加勒比族人。主诉:头痛和视物模糊3周。患者在乌干达度假3周期间,为了预防疟疾,口服多西环素0 .1,qd。体检:右眼视力6 / 9,左眼6 / 5。视乳头严重水肿伴出血和棉绒样斑点,右眼更明显。MRI This article reports doxycycline caused by acute severe intracranial hypertension in 2 cases, of which 1 case of permanent visual impairment. Example 1, female, 21 years old. African Caribbean. Chief complaint: headache and blurred vision 3 weeks. Patients during oral holiday in Uganda orally administered doxycycline o.1, qd for malaria prevention during 3 weeks. Physical examination: right eye vision 6/9, left eye 6/5. Severe papilledema with hemorrhage and lint-like spots, the right eye is more obvious. MRI