探寻药用植物及其临床应用的发展趋势(英文)

来源 :中国药理学与毒理学杂志 | 被引量 : 0次 | 上传用户:wf1899
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Plant biodiversity has been source of myriad forms of natural substances utilized in similarly multiple ways.The history of medicinal and aromatic plant(MAP)utilization dates back to the beginnings of mankind.Our forefathers used plants they could find in nature,to ease,cure their sufferings,illnesses,or heal their wounds.This type of approach has survived in the traditional medicinal(TM)uses,until today,since nearly 80% of the world population still relies on MAPs in their medications(Akerele,1992).Especially rich are the traditions in China and India,where TMs have been used for thousands of years.The use of TM,however,goes well beyond these countries.It has been estimated that more than 1.5 billion people all over the world are trusting in the efficacy and safety of Chinese medicine(Wang and Franz,2014).The renaissance of MAP-use in the high-income countries has brought about different types of use i.e.:in the form of Herbal Medicines(CAM=Complementary and Alternative Medicine).MAPs have become″industrial products″with versatile and innovative new concepts in phytotherapy and veterinary medicine,aromatherapy,nutraceuticals,cosmeceuticals,animal welfare,etc.New,innovative,value added applications include MAP use in functional foods,animal husbandry,as well as plant protection in agriculture.The versatile utilization of essential oils is most promising.MAPs are sourced from both wild-crafting and cultivation,where quality is primarily determined by the genotype,the environment and the conditions during the life cycle of the plant.Processing to preserve/isolate their active principles is an additional precondition for the safety and efficacy in use.Current areas of utilization constitute powerful drivers for the exploitation of these natural resources.Increasing demands,coupled with the already limited availability and potential exhaustion of natural resources,make it necessary to take stock of both our resources and our knowledge regarding research and development,production,trade and utilization,especially in view of sustainability National/international regulatory authorities have elaborated guidelines(GACP,GMP and GLP)to be included in quality assurance systems.The entire production system should observe these practices and this fact should be continuously documented,certified.Modern approaches in production and use have called attention to the importance of quality,safety and efficacy of both MAPs and their produce.There is also a need to ensure the quality of medicinal plant products by using modern sample preparation and control techniques as well as suitable standards.In Europe,this regards also the quality of TCM herbals.Their quality assurance systems should guarantee that they can be freely imported into the European Union and other Western European Countries(Wang and Franz,2014).A new aspect in quality assurance is the trend for the protection of′geographical indication′(GI)botanicals in the context of intellectual property rights.MAPs will also maintain their importance in the search for new,valuable sources of drugs and lead compounds.The ultimate aim would be to use MAPs with welldefined and constant composition.There is a need to ensure the quality of medicinal plant products by using modern sample preparation and control techniques.Thepharmacological effects of herbs are caused by the interaction several biologically active principles,therefore,the present clinical testsaimed at single chemicals,are also not really adequate.Todate,the lesson worthily worded by the Chiang Mai Declaration(1988)is more than valid:″Let us save plants that Save Lives″. Plant biodiversity has been source of myriad forms of natural substances utilized in similarly multiple ways.The history of medicinal and aromatic plant (MAP) utilization dates back to the beginnings of mankind.Our forefathers used plants they could find in nature, to ease, cure their sufferings, illnesses, or heal their wounds.This type of approach has survived in the traditional medicinal (TM) uses, until today, since nearly 80% of the world population still relies on MAPs in their medications (Akere, 1992) .Especially rich are the traditions in China and India, where TMs have been used for thousands of years. The use of TM, however, goes well beyond the countries. It has been estimated that more than 1.5 billion people all over the world are trusting in the the efficacy and safety of Chinese medicine (Wang and Franz, 2014). The renaissance of MAP-use in the high-income countries has brought about different types of use ie: in the form of Herbal Medicines (CAM = Complementary and Alternative Medicine). MAPs have become “industrial products” with versatile and innovative new concepts in phytotherapy and veterinary medicine, aromatherapy, nutraceuticals, cosmeceuticals, animal welfare, etc. New, innovative, value added applications include MAP use in functional foods, animal husbandry, as well as plant protection in agriculture. versatile utilization of essential oils is most promising. MAPs are sourced from both wild-crafting and cultivation, where quality is defined by the genotype, the environment and the conditions during the life cycle of the plant. Processing to preserve / isolate their active principles is an additional precondition for the safety and efficacy in use. Current areas of utilization for the drivers for the exploitation of these natural resources. Increasing demands, coupled with the already limited availability and potential exhaustion of natural resources, make it necessary to take stock of both our resources and our knowledge regarding research and developm ent,production, trade and utilization, especially in view of sustainability of national / international regulatory authorities have elaborated guidelines (GACP, GMP and GLP) to be included in quality assurance systems. The entire production system should observe these practices and this fact should be continuously documented, certified.Modern approaches in production and use have called attention to the importance of quality, safety and efficacy of both MAPs and their produce.There’s also a need to ensure the quality of medicinal plant products by using modern sample preparation and control techniques as well. as suitable standards.In Europe, this condition also the quality of TCM herbals. their quality assurance systems should guarantee (they may be welded into the European Union and other Western European Countries (Wang and Franz, 2014). A new aspect in quality assurance is the trend for the protection of ’geographical indication’ (GI) botanicals in the context of intellectual property rights .MAPs will also maintain their importance in the search for new, valuable sources of drugs and lead compounds. Ultimate Ultimate would be to use MAPs with welldefined and constant composition. There is a need to ensure the quality of medicinal plant products by using modern sample preparation and control techniques. Thepharmacological effects of herbs are caused by the interaction several biologically active principles, therefore, the present clinical testsaimed at single chemicals, are also not really adequate.Todate, the lesson worthily worded by the Chiang Mai Declaration (1988) is more than valid: “Let us save plants that Save Lives”.
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