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目的:探讨狼毒水提物对大鼠佐剂性关节炎模型治疗作用及初步机制。方法:采用佐剂关节炎大鼠模型,以雷公藤多苷为阳性对照药物,观察及检测狼毒水提物对大鼠一般状况、关节炎肿胀度、关节炎评分、胸腺指数、脾脏指数、肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)水平的影响。结果:狼毒水提物能抑制大鼠足趾继发性肿胀继发性肿胀,能降低关节炎指数,降低关节组织病理评分。结论:狼毒水提物能够抑制大鼠佐剂性关节炎发生发展。
Objective: To investigate the therapeutic effect and preliminary mechanism of water extract of Stellera chamaejasme on adjuvant arthritis in rats. Methods: The rat model of adjuvant arthritis was used. Tripterygium wilfordii glycosides was used as positive control drug. The effects of water extract of Euphorbia pulcherrima on the general condition, arthritis swelling, arthritis score, thymus index, spleen index, Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels. Results: Euphorbia pulchromus water extract can inhibit the secondary swelling of the rat toe secondary swelling, can reduce the arthritis index, reduce the joint histopathological score. Conclusion: Efflux extract can inhibit the occurrence and development of adjuvant arthritis in rats.