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目的探讨肥大细胞(MC)在乳腺导管内上皮瘤变(DIN)与浸润性导管癌中的表达及其对该2类疾病诊断及远期预后判断的意义,并探讨该2两类患者发现年龄方面的变化状态,以揭示其流行病学特点。方法MC检测用MC和胶原纤维组合染色法,组织学分级用Patley和Scarff方法。结果2类75例患者(DIN20例、乳腺浸润性导管癌55例)MC数量差异有统计学意义(H=12.08,P<0.01);55例乳腺浸润性导管癌中的Ⅰ、Ⅱ、Ⅲ级患者的MC数量差异有统计学意义(H=19.12,P<0.01)。2类75例患者的病变发现年龄差异有统计学意义(H=16.68,P<0.01)。结论MC数量与组织学分级结果,存在明显的对应关系,即两类患者的MC数量是DIN>乳腺浸润性导管癌;乳腺浸润性导管癌中Ⅰ、Ⅱ、Ⅲ级患者的MC数量是Ⅰ>Ⅱ>Ⅲ,差异有统计学意义(H=9.12,P<0.01)。说明MC数量可作为该两类疾病诊断及远期预后判断的参考指标。
Objective To investigate the expression of mast cells (MC) in intraductal epithelial neoplasia (MDC) and infiltrating ductal carcinoma and its significance in the diagnosis and long-term prognosis of these two kinds of diseases. The state of change in order to reveal its epidemiological characteristics. Methods The MC was stained with a combination of MC and collagen fibers and histologically graded using Patley and Scarff methods. Results There were significant differences in the number of MC between 75 patients (20 cases of DIN, 55 cases of infiltrating ductal breast cancer) in two groups (H = 12.08, P <0.01), and Ⅰ, Ⅱ and Ⅲ in 55 cases of invasive ductal carcinoma The number of patients with MC was significantly different (H = 19.12, P <0.01). There were significant differences in age of onset of lesions between the two groups of 75 patients (H = 16.68, P <0.01). Conclusion There is a clear correlation between the number of MC and histological grading. The number of MC in both groups is DIN> invasive breast ductal carcinoma. The number of MC in grade Ⅰ, Ⅱ and Ⅲ breast invasive ductal carcinoma is Ⅰ> Ⅱ> Ⅲ, the difference was statistically significant (H = 9.12, P <0.01). Explain the number of MC can be used as a reference for the diagnosis of these two types of diseases and long-term prognosis.