Monitoring tire pressure of cars and signaling abnormal conditions is an important means to prevent deadly accidents. Large achievements have been gained, especially in direct tire pressure monitoring system(TPMS). But there has been rarely research on indirect TPMS in the world. In China, the research on indirect TPMS is almost lacking. The international research on the indirect monitoring tire pressure method is mainly based on measuring and comparing the rotating speed of wheels. But it is very difficult to measure wheel rotating speed accurately because of the influence of many random factors. In this paper, the authors propose a new method in which the tire pressure can be monitored indirectly. This method can be used for tire calibration, wheel speed frequency standardization, wheel speed frequency comparison, and abnormal tire pressure determination. The pulse frequencies from wheel speed sensors of ABS are used to indicate tire deformation. Because the frequency has a relationship with tire deformation, the tire deformation reflects the tire pressure. Small sample statistics is used in the new method to increase the accuracy, and the experimental samples using the principle of the new method have been made and tested. The result of vehicle tests on road demonstrates that the method is efficient and accurate to monitor tire pressure. The research has positive potential for developing products.