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目的分析Notch1与Cyclin D1在乳腺增生症与乳腺癌中的表达情况。方法选取乳腺癌患者110例作为A组,乳腺增生症患者110例作为B组,并选择同期入医院体检的健康者110例作为C组。采用免疫组织化学方法检测3组Notch1受体蛋白和Cyclin D1蛋白在组织中的表达。结果 Notch1在A组和C组的阳性表达率低于B组和C组(P<0.05),Notch1在B组和C组中的表达率无显著性差异(P>0.05);3组Cyclin两两比较差异均有统计学意义(P<0.05)。结论 Cyclin D1在乳腺癌和乳腺增生中高表达,以乳腺癌表达最高;Notch1在乳腺癌中低表达,在乳腺增生中的表达与正常组织无显著性差别。
Objective To analyze the expression of Notch1 and Cyclin D1 in breast hyperplasia and breast cancer. Methods One hundred and ten patients with breast cancer were selected as Group A and 110 patients with hyperplasia of mammary glands as Group B. One hundred and one healthy subjects who entered the hospital during the same period were selected as Group C. Immunohistochemistry was used to detect the expression of Notch1 receptor protein and Cyclin D1 protein in the three groups. Results The positive expression rates of Notch1 in group A and group C were lower than those in group B and group C (P <0.05), but not in group B and group C (P> 0.05) The differences between the two groups were statistically significant (P <0.05). Conclusions Cyclin D1 is highly expressed in breast cancer and breast hyperplasia, and is highest in breast cancer. Notch1 is low in breast cancer and no significant difference in normal breast tissues.