先证者Ⅱ_3,男,79岁。因手足关节肿痛反复发作12年入院。发病时无明显诱因,出现右(足母)趾、蹠趾、左腕关节。第1掌指关节红肿,疼痛剧烈,反复发作。近儿年来手足关节频繁交替出现上述症状,血尿酸高于正常。患者否认患过血液病,肾脏病,高血压心血管病及长期服用药物史。检查:血压19/11kPa,心、肺、肝、脾无异常。左腕关节。第1掌指关节,足(足母)趾关节肿胀, Proof of II_3, male, 79 years old. Repeated episodes of hand, foot and joint swelling and pain for 12 years admitted to hospital. No obvious incentive to onset, there right (foot mother) toe, metatarsophalangeal, left wrist. The first metacarpophalangeal joint swelling, severe pain, recurrent. In recent years, frequent hand-foot joints alternating the above symptoms, serum uric acid higher than normal. Patients denied suffering from blood diseases, kidney disease, hypertension, cardiovascular disease and long-term medication history. Check: blood pressure 19 / 11kPa, heart, lung, liver, spleen and no abnormalities. Left wrist. The first metacarpophalangeal joint, foot (foot mother) toe joint swelling,