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大约30%的蛛网膜下腔出血(SAH)患者因血管痉挛出现迟发的神经功能损害,其中一半死亡或留下严重神经功能缺损。作者通过脑大动脉痉挛的体外研究,证实人和犬的脑大动脉对从SAH几天后的病人处获取的脑脊液有明显收缩反应;其中5-羟色胺(5-HT)的血管收缩活性最强,而S-HT拮抗剂二甲麦角新硷、赛庚啶等在低浓度时不能抑制由5-HT所引起的脑大动脉痉挛。原因是有两种5-HT受体:高亲和力的5-HT_1受体和低亲和力的5-HT2受体。实验揭示犬基底动脉对5-HT的收缩反应是由于5-HT_1受体之故,但目前还没有5-HT_1受体拮抗剂。有关资料表明存在于肌动蛋白和肌球蛋白丝内游离钙的浓度决定其产生收缩的程度,调节细胞内收缩蛋白质中游离钙的量,就可调节平滑肌细胞的
Approximately 30% of patients with subarachnoid hemorrhage (SAH) develop delayed neurological impairment due to vasospasm, and half of them die or leave severe neurological deficits. In vitro studies in patients with cerebral arteriolar spasm demonstrated that the cerebral aorta of humans and dogs had a pronounced contractile response to cerebrospinal fluid obtained from patients several days after SAH, of which serotonin (5-HT) had the most vasoconstrictor activity and S-HT antagonists methicillin, cyproheptadine and other low concentration can not inhibit 5-HT caused by cerebral aortic spasm. The reason is that there are two types of 5-HT receptors: the high-affinity 5-HT_1 receptor and the low-affinity 5-HT2 receptor. Experiments revealed that the basilar artery contractile response to 5-HT is due to the 5-HT1 receptor, but no 5-HT1 receptor antagonist is currently available. The data show that the presence of actin and myosin filaments within the concentration of free calcium determines the degree of contraction, regulating the amount of intracellular contractile protein in the amount of free calcium, you can regulate the smooth muscle cells