癌细胞对药物发生抗药性是影响抗癌疗效的重要因素之一,研究抗药性机理对于提高化疗疗效,发展新抗癌药有重要的实际意义。前文“抗癌药物抗药性的细胞生物化学机理及其拮抗方法”(本刊1982,1(2):130)有过全面介绍。现将近年来新的研究进展概述如下。 Cancer resistance to drugs is one of the important factors affecting anti-cancer efficacy. Studying the mechanism of drug resistance has important practical significance for improving the efficacy of chemotherapy and developing new anti-cancer drugs. The previous article “Cellular biochemical mechanism and antagonistic methods of anticancer drug resistance” (Journal of 1982, 1 (2): 130) has been fully described. The new research progress in recent years is summarized as follows.