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迄今已有8项动物实验和3项流行病学研究证明阿斯匹林或其它非类固醇抗炎药(NSAID)能降低大肠癌危险。现首次对此行病例对照研究,并对癌前病变大肠息肉的作用也予以探讨。 病人均是 1982~1991年间 Roswell Park癌研究所的就诊者。病人组分三部分:首次发病的原发性结肠癌490例;首次发病的原发性直肠癌340例;无任何恶性病变的结肠(68%)或直肠(32%)息肉212例。所有病人年龄均18岁以上,用阿斯匹林者时间均超过1年。对照组分两部分:健康普查者1138例;无癌无消化器官病变的住院者524例。按阿期匹林使用期限、性别、年龄、居住地理位置和教育状况调整后,采用Logistic多元回归法,将用阿斯匹林超
Up to now, 8 animal experiments and 3 epidemiological studies have demonstrated that aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) can reduce the risk of colorectal cancer. For the first time this case-control study, and the role of precancerous colorectal polyps are also discussed. All the patients were from the Roswell Park Cancer Institute from 1982 to 1991. The patient consisted of three components: 490 cases of primary colon cancer, and 340 cases of primary rectal cancer. There were no malignant lesions in the colon (68%) or rectum (32%) in 212 cases of polyps. All patients were 18 years of age or older and aspirin used more than 1 year. The control components consisted of two parts: 1138 healthy census patients and 524 hospitalized patients without cancer or digestive lesions. After adjusting for the age, sex, age, geographic location, and educational status of aspirin, Logistic multivariate regression method will be used to use aspirin.