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目的探讨新生儿缺氧缺血性脑病患儿血管内皮生长因子(VEGF)、血清肌酸激酶(CK)、肌酸激酶脑型同工酶(CK-BB)的动态变化及其意义,以期为新生儿缺氧缺血性脑病患儿的早期诊断提供参考依据。方法选取2012年1月—2013年11月间来新生儿科进行住院治疗的102例新生儿缺氧缺血性脑病患儿和30例正常新生儿分别在生后1天内、第3天、第7天采集股静脉血,采用ELISA双抗体夹心法集中检血浆VEGF水平,采用酶联免疫法测定CK、CK-BB水平。结果病例组的患者在出生后第1天、第3天、第7天VEGF、CK及CK-BB的水平均明显高于对照组,差异均有统计学意义(P<0.01)。结论血清VEGF、CK、CK-BB的检测与分析在新生儿缺氧缺血性脑病的早期诊断中具有非常重要的临床意义,早期检验3种指标可以对HIE患儿早期诊断,使患儿能够及时接受有效的临床治疗,从而减少了HIE导致的严重不良预后。
Objective To investigate the dynamic changes of vascular endothelial growth factor (VEGF), serum creatine kinase (CK) and creatine kinase (CK-BB) in neonates with hypoxic-ischemic encephalopathy Neonatal hypoxic-ischemic encephalopathy in children with early diagnosis provide a reference. Methods A total of 102 cases of neonatal hypoxic-ischemic encephalopathy and 30 normal newborn infants admitted to the neonatology department from January 2012 to November 2013 were enrolled in the study. One day after birth, the third day, the seventh Blood samples were taken from the femoral vein, and plasma VEGF levels were detected by ELISA double antibody sandwich method. The levels of CK and CK-BB were measured by enzyme-linked immunosorbent assay. Results The serum levels of VEGF, CK and CK-BB on the 1st day, 3rd day and 7th day after birth in the case group were significantly higher than those in the control group (P <0.01). Conclusion The detection and analysis of serum VEGF, CK, CK-BB have very important clinical significance in the early diagnosis of neonatal hypoxic-ischemic encephalopathy. Early detection of three indexes can make early diagnosis of HIE children, Timely and effective clinical treatment, thus reducing the serious adverse prognosis caused by HIE.