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近20年对葡萄胎患者的诊断、处理及长期随访已统一化,并认为葡萄胎后多次连续生育多真正的100%治愈。测定血清hCG的水平以示有无复发。随访期间口服避孕药(OC)为理想的避孕方法,可避免妊娠干扰临床的评价及处理。Stone(1976)的回顾性研究指出,葡萄胎清宫后OC明显增加滋养层疾患的复发率,且较其它避孕方法推迟hCG恢复正常水平。本文对216例经组织学证实的完全性葡萄胎患者进行前瞻性研究以考验上述假说,随机将病人分为两组:(1)OC组:服Ovral brand含50μg乙炔基雌二醇及0.5mg18-甲基炔诺酮;(2)屏障避孕组。两组病人的年龄、孕产次、子宫大小
In the past 20 years, the diagnosis, treatment and long-term follow-up of patients with hydatidiform moles have been unified, and it is believed that the hydatidiform moles are more than 100% cured after multiple consecutive births. Serum hCG levels were measured to show that there was no recurrence. Oral contraceptives (OC) during follow-up as the ideal method of contraception, to avoid the clinical evaluation of pregnancy disorders and treatment. A retrospective study by Stone (1976) pointed out that OC significantly increases the recurrence rate of trophoblastic disorders after hydatidiform mole cleavage and delays hCG return to normal than other contraceptive methods. In this paper, 216 patients with histologically proven complete hydatidiform mole were prospectively tested to test the above hypothesis. Patients were randomly divided into two groups: (1) OC group: Ovral brand containing 50 μg ethinyl estradiol and 0.5 mg 18 - norgestrel; (2) barrier contraceptive group. Two groups of patients age, motherhood, uterine size