论文部分内容阅读
目的探讨宫颈机能不全孕妇抗核抗体(ANA)与抗心磷脂抗体(ACA)表达的临床意义。方法选取2014年1月-2016年6月于本院就诊的60例宫颈机能不全患者作为研究组,选取同期与研究组相匹配的60例健康孕妇作为对照组,比较2组ANA阳性率、ACA阳性率,同时比较研究组患者中晚期流产1次、2次~3次、3次以上者的ANA阳性率、ACA阳性率。结果研究组ANA阳性率、ACA阳性率以及ANA、ACA双阳性率均显著高于对照组,差异有统计学意义(P<0.01);60例宫颈机能不全患者中,晚期流产次数为1次者共32例,2次~3次者16例,3次及以上者12例,其ANA阳性率分别为12.5%、41.2%、83.3%,ACA阳性率分别为12.5%、37.5%、83.3%,不同晚期流产次数患者的ANA阳性率、ACA阳性率差异均有统计学意义(P<0.01)。结论宫颈机能不全患者存在ANA、ACA高表达,且宫颈机能不全患者晚期流产次数越多,ANA及ACA的阳性率越高,检测ANA与ACA对辅助诊断宫颈机能不全、预测流产发生具有重要意义。
Objective To investigate the clinical significance of anti-nuclear antibody (ANA) and anticardiolipin antibody (ACA) expression in pregnant women with cervical incompetence. Methods Sixty patients with cervical insufficiency from January 2014 to June 2016 in our hospital were selected as the study group. Sixty healthy pregnant women matched with the study group were selected as the control group. The positive rates of ANA, ACA Positive rate, at the same time, compared the study group patients with advanced miscarriage 1, 2 to 3 times, more than 3 times the ANA positive rate, ACA positive rate. Results The positive rate of ANA, the positive rate of ACA and the positive rate of ANA and ACA in the study group were significantly higher than those in the control group (P <0.01). In 60 patients with cervical incompetence, the number of late miscarriage was 1 ANA positive rates were 12.5%, 41.2%, 83.3%, ACA positive rates were 12.5%, 37.5%, 83.3% respectively in 32 cases, 2 times to 3 times in 16 cases and 3 times or more in 12 cases. The difference of ANA positive rate and ACA positive rate of patients with different late miscarriage times were statistically significant (P <0.01). Conclusions ANA and ACA are highly expressed in patients with cervical incompetence. The more the number of late abortion is, the higher the positive rate of ANA and ACA is. The detection of ANA and ACA is of great significance for the diagnosis of cervical incompetence and prediction of miscarriage.