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为明确克雷伯杆菌对临床常用抗菌药物的敏感性， 收集了１９９６年度武汉市１３ 家大中型医院住院免疫低下患者体内分离的克雷伯杆菌， 并用琼脂板稀释法测定１６ 种抗菌药物的最低抑菌浓度。结果共得细菌１５２ 株， 以肺炎克雷伯杆菌为主 （１２８ 株）， 尚有臭鼻克雷伯杆菌 （１３株）、催产克雷伯杆菌 （９ 株）、鼻硬结克雷伯杆菌 （２ 株）。药敏测定表明： β－内酰胺类中除头孢他啶、依米配南的ＭＩＣ９０≤１６ μｇ／ｍ ｌ， 其它对克雷伯杆菌的ＭＩＣ９０ 均较高， 但阿米卡星、环丙沙星的ＭＩＣ９０仅为８ 和１ μｇ／ｍ ｌ。臭鼻和催产克雷伯杆菌对部分抗菌药物的耐药性高于肺炎克雷伯杆菌。比较不同部位分离的肺炎克雷伯杆菌药敏，结果表明：非呼吸道分离的肺炎克雷伯杆菌对药物的敏感性总体上低于呼吸道分离的菌株。
To clarify the sensitivity of Klebsiella to commonly used antimicrobial agents in clinical practice, Klebsiella was isolated from in-hospital immunocompromised patients in 13 large and medium-sized hospitals in Wuhan in 1996 and the lowest of 16 antimicrobial agents was determined by agar plate dilution Bacteriostatic concentration. Results A total of 152 strains of bacteria were isolated from Klebsiella pneumoniae (128 strains), Klebsiella spp. (13 strains), Klebsiella oxytoca (9 strains), Klebsiella pneumoniae 2 strains). Susceptibility testing showed that the MIC90 of β-lactam except ceftazidime and imipenem was higher than or equal to 16 μg / ml, while the MIC90 values were higher for Klebsiella, but amikacin, ciprofloxacin The MIC90 is only 8 and 1 μg / ml. Odor and oxytocin Klebsiella resistance to some antimicrobial drugs than Klebsiella pneumoniae. The Klebsiella pneumoniae susceptibility isolated from different sites was compared. The results showed that Klebsiella pneumoniae isolated from non-respiratory tract was generally less sensitive to the drug than the strain isolated from the respiratory tract.