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目的:研究草酸铂(OXA)、氟尿嘧啶(5蛳Fu)及亚叶酸钙(CF)联合化疗对晚期胃癌的临床疗效。方法:草酸铂(OXA)130 mg/m2,静脉滴注3 h,第1天;亚叶酸钙200 mg/m2静脉滴注2 h后,使用5蛳Fu 600 mg/m2静脉滴注6 h,第1天~第5天,每2周重复。连用2周期为1疗程,然后判定疗效。结果:入组观察32例,其中行原发灶均切除者14例,未切除者18例。可评价疗效者32例,其中完全缓解(CR)3例(9.4 %),部分缓解(PR)12例(37.5 %),稳定(SD)10例(31.2 %),进展7例(21.9 %),总有效率(ORR)46.9 %,初治ORR 34.4 %,复治ORR 12.5 %,中位进展期(mTTP)5.4个月,中位总生存期12.5个月。32例中不良反应为Ⅲ度或Ⅳ度者11例,其中白细胞减少8例(25 %),血小板减少2例(6.3 %),恶心呕吐1例。结论:OXA+CF+5蛳Fu是治疗晚期胃癌安全有效的方案。
Objective: To study the clinical efficacy of oxaliplatin (OXA), fluorouracil (5 蛳 Fu) and leucovorin (CF) in combination with chemotherapy on advanced gastric cancer. Methods: OXA 130 mg / m2 was given intravenously for 3 hours on the first day. After levofloxacin 200 mg / m2 was given intravenously for 2 hours, From day 1 to day 5, repeat every 2 weeks. Use 2 cycles for a course of treatment, and then determine the efficacy. Results: 32 cases were enrolled into the study, including 14 cases with primary tumor resection and 18 cases without resection. Thirty-two patients (32.9%) were evaluated as complete remission (CR), 12 (37.5%) with partial remission (PR), 10 (31.2%) with stable (SD) , Total effective rate (ORR) 46.9%, initial treatment ORR 34.4%, retreatment ORR 12.5%, median progression (mTTP) 5.4 months, median overall survival 12.5 months. Among the 32 cases, 11 had grade Ⅲ or Ⅳ adverse reactions, of which 8 (25%) had leukopenia, 2 (6.3%) had thrombocytopenia and 1 had nausea and vomiting. Conclusion: OXA + CF + 5% Fu is a safe and effective treatment for advanced gastric cancer.