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目的:研究加替沙星对住院患者血糖的影响,为临床安全应用该药提供科学依据。方法:2007年5月至10月期间接受加替沙星或左氧氟沙星治疗的475例来自13所医院的住院患者纳入随访研究。其中加替沙星组230例,左氧氟沙星组245例。患者的给药剂量均为400 mg/d,静脉滴注,用药时间为7 d。给药前、给药后第4天及停药后测定患者的血糖水平。结果:停药后高血糖和血糖升高的发生率,加替沙星组高于左氧氟沙星组(分别为13.91%对6.53%和18.70%对9.80%),差异有统计学意义(P<0.01)。停药后血糖降低的发生率,左氧氟沙星组高于加替沙星组(36.73%对22.17%),差异有统计学意义(P<0.01)。加替沙星组停药后高血糖、血糖升高及降低的发生率,糖尿病患者分别为12.90%、17.74%及22.58%,非糖尿病患者分别为14.29%、19.05%和24.40%,差异无统计学意义(均P>0.05)。结论:加替沙星可致血糖升高或降低,因此临床使用时应予以注意,并应作血糖水平测定。
Objective: To study the effect of gatifloxacin on blood glucose in hospitalized patients and provide a scientific basis for the clinical safety of the drug. METHODS: 475 inpatients from 13 hospitals treated with gatifloxacin or levofloxacin during May-October 2007 were included in the follow-up study. Among them, 230 were gatifloxacin group and 245 were levofloxacin group. The patient’s dosage was 400 mg / d, intravenous infusion, medication time was 7 d. The patient’s blood glucose level was measured before drug administration, on the fourth day after drug administration, and after drug withdrawal. Results: The incidence of hyperglycemia and hyperglycemia after stopping treatment was higher in gatifloxacin group than in levofloxacin group (13.91% vs 6.53% and 18.70% vs 9.80%, respectively), the difference was statistically significant (P <0.01) . The incidence of hypoglycaemia after drug withdrawal was higher in levofloxacin group than in gatifloxacin group (36.73% versus 22.17%), with significant difference (P <0.01). In the gatifloxacin group, the incidences of hyperglycemia, hyperglycemia, and the incidence of depression were 12.90%, 17.74% and 22.58% in patients with diabetes and 14.29%, 19.05% and 24.40% in non-diabetic patients respectively, with no statistical difference Significance (both P> 0.05). Conclusion: Gatifloxacin can cause blood sugar to increase or decrease, so it should be noticed in clinical use, and blood glucose level should be determined.