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目的探讨超生理雌孕激素水平在胚胎移植助孕后异位妊娠发生中的意义。方法对1997年9月至2006年10月在河北医科大学第二医院生殖医学科行新鲜胚胎和冻融胚胎移植获得妊娠407周期进行回顾性分析。结果新鲜胚胎和冻融胚胎移植周期异位妊娠率分别为7.45%、1.18%,差异有统计学意义(χ2=4.5958,P=0.0321)。新鲜周期中异位妊娠组与非异位妊娠组输卵管因素比例分别为79.2%、56.4%,异位妊娠组胚胎移植后3d血清孕酮[(120.1±32.3)nmol/L]明显高于非异位妊娠组[(89.7±43.7)nmol/L],差异均有统计学意义(P<0.05)。结论超生理雌孕激素水平及其比例失调可能与胚胎移植助孕后异位妊娠发生有关,并在异位妊娠的发生中与输卵管受损联合起作用。
Objective To investigate the significance of estrogen and progesterone in the development of ectopic pregnancy after embryo transfer. Methods Retrospective analysis was performed on 407 cycles of pregnancy obtained from fresh embryo and frozen-thawed embryo transfer in the Second Affiliated Hospital of Hebei Medical University from September 1997 to October 2006. Results The rate of ectopic pregnancy in fresh embryo and frozen-thawed embryo was 7.45% and 1.18%, respectively, with significant difference (χ2 = 4.5958, P = 0.0321). The proportion of tubal factors in ectopic pregnancy group and non-ectopic pregnancy group were 79.2% and 56.4%, respectively. The serum progesterone (120.1 ± 32.3 nmol / L) in ectopic pregnancy group after embryo transfer was significantly higher than that in non-ectopic pregnancy group Bit pregnancy group [(89.7 ± 43.7) nmol / L], the differences were statistically significant (P <0.05). Conclusion The levels of estrogen and progesterone and their imbalances may be related to the occurrence of ectopic pregnancy after embryo transfer to pregnancy and the combined effect of tubal damage and ectopic pregnancy.