抗癫痫的新药癫健安又名丙缬草酰胺(Valpra-mide),化学名二丙基乙酰胺(Di-n-propylacetamide)或2-丙基缬草酰胺(2-propylvaleramide)。国外商品名Depamide,1977年法国有商品出售。我厂1978年起对该药进行研制,工艺路线采用氰乙酸酯为起始原料,经四步反应制得。样品经熔点测定、元素分析、红外、核磁、质谱测试,确证其结构为丙缬草酰胺。合成工艺通过小试和中试放大,提供了药理和临床样品。经全国16所医院进行临床观察346例,取得较为满意的结果。 Antiepileptic New Drugs Epilepsy also known as Valpra-mide, chemical name Di-n-propylacetamide or 2-propylvaleramide. Foreign trade name Depamide, 1977 French goods for sale. I plant since 1978 on the drug development, process route using cyanoacetate as the starting material, the four-step reaction. The sample was determined by melting point, elemental analysis, infrared, nuclear magnetic resonance and mass spectrometry to confirm its structure was valproamide. The synthesis process provides pharmacological and clinical samples through small and pilot amplification. After the clinical observation of 346 cases in 16 hospitals across the country, more satisfactory results were obtained.