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目的探讨糖尿病肾病的规范化治疗对患者尿蛋白量及肾功能的影响。方法将60例糖尿病肾病患者随机分为治疗组和对照组,治疗组严格控制血糖、血压、血脂至目标值;对照组上述指标虽得到控制,但未完全达标,疗程为6个月,观察两组患者治疗前后24 h尿蛋白定量(24hUP)及肾功能水平的变化。结果治疗组治疗后24hUP、血肌酐、尿素氮和胱抑素C较同组治疗前及对照组治疗后均降低(P均<0.01)。结论严格控制糖尿病肾病患者血糖、血压及血脂水平能够延缓糖尿病肾病病程进展。
Objective To investigate the effect of standardized treatment of diabetic nephropathy on urinary protein and renal function in patients. Methods Sixty diabetic patients with diabetic nephropathy were randomly divided into treatment group and control group. The treatment group underwent strict control of blood glucose, blood pressure and blood lipid to the target value. Although the above indexes in the control group were controlled but not completely reached, the course of treatment was 6 months. 24 h urinary protein (24hUP) and renal function changes in patients before and after treatment. Results After 24hUP treatment, serum creatinine, blood urea nitrogen and cystatin C were lower in the treatment group than those in the control group before and after treatment (all P <0.01). Conclusion Strict control of patients with diabetic nephropathy blood glucose, blood pressure and lipid levels can delay the course of diabetic nephropathy.