目的探讨婴幼儿脓毒症临床特征,分析其预后危险因素。方法 116例脓毒症患儿作为研究对象,采用回顾性分析和病例对照方法对患儿的临床特征、发病状况、预后进行分析,依照患儿随访情况将其分为存活组(106例)与死亡组(10例),采用单因素分析和Logistic回归分析方法对脓毒症预后危险因素进行分析。结果本组116例脓毒症患儿中,非危重患儿102例,极危重+危重患儿14例(包括多器官功能不全11例、脓毒性休克7例,其中4例合并多器官功能不全和脓毒性休克),死亡10例[原发部位:肺部7例(70.00%),中枢神经系统2例(20.00%),消化道1例(10.00%)]。两组患儿的入院前发热时间、住院时间、年龄、非危重率、脏器受累数≥3个发生率、低血糖发生率、应激高血糖发生率比较,差异均具有统计学意义(t=6.347、25.829、7.721,χ~2=47.586、17.510、9.005、17.990,P<0.05)。多因素Logistic回归分析结果显示,脓毒症严重程度和脏器受累数是导致婴幼儿死亡的独立危险因素(P<0.05)。结论婴幼儿脓毒症多见1岁以下婴幼儿,具有较高病死率,呼吸道和消化道是主要的原发感染病灶;婴幼儿脓毒症程度越重、受累器官数越多则患儿承受的死亡风险就越大。 Objective To investigate the clinical characteristics of infant sepsis and analyze its prognostic risk factors. Methods One hundred and sixty - six children with sepsis were enrolled in this study. The clinical features, morbidity and prognosis of the children were analyzed retrospectively and case - control. According to their follow - up, they were divided into survival group (106 cases) and control group Death group (n = 10). Univariate analysis and logistic regression analysis were used to analyze the risk factors of sepsis prognosis. Results Among the 116 patients with sepsis, 102 were non-critically ill children, and 14 were critically ill and critically ill children (including 11 cases of multiple organ dysfunction and 7 cases of septic shock, of which 4 cases were complicated with multiple organ dysfunction And septic shock), and 10 died [primary site: 7 cases of lung (70.00%), 2 cases of central nervous system (20.00%) and 1 case of digestive tract (10.00%)]. Pre-admission fever, length of hospital stay, age, non-critical rate, organ involvement ≥ 3 incidence, incidence of hypoglycemia and stress hyperglycemia in both groups were statistically significant (t = 6.347, 25.829, 7.721, χ ~ 2 = 47.586, 17.510, 9.005, 17.990, P <0.05). Multivariate Logistic regression analysis showed that the severity of sepsis and organ involvement were independent risk factors for infant mortality (P <0.05). Conclusion Infants and young children sepsis more common in infants and young children under 1 year old, with high mortality, respiratory and gastrointestinal tract is the main primary infection; infants and young children more severe sepsis, the number of organs involved in the more children bear The greater the risk of death.