Objective: The aim of this study was to report the oncological result of the treatment of 12 patients with osteosarcoma sustaining pathologic fracture. Methods: There were 9 male and 3 female patients, the average age was 17.6 years (ranged, 11–34 years). All patients received neoadjuvant chemotherapy, wide margin resection was achieved and skeletal reconstruction was done with locally designed and custom-manufactured prosthesis. Follow-up examination was carried out at an average of 36 months (range from 12–94 months). Results: Nine patients had survived and of these 8 patients were free from disease while one patient was alive with disease. The functional result (using the 30-point rating system of the Musculoskeletal Tumor Society) was excellent in three (25%), good in six (50%), fair in three (25%). Conclusion: The performance of a limb-salvage procedure in a patient with pathologic fracture, particularly for one that unites following chemotherapy, does not significantly increase the risk of local recurrence or survival. Methods: There were 9 male and 3 female patients, the average age was 17.6 years (ranged, 11-34 years) All patients received neoadjuvant chemotherapy, wide margin resection was achieved and skeletal reconstruction was done with locally designed and custom-manufactured prosthesis. Follow-up examination was carried out at an average of 36 months (range from 12-94 months). Results: Nine functional factors (using the 30-point rating system of the Musculoskeletal Tumor Society) were excellent in three (25%), good in six (50%), fair in three (25%). Conclusion: The performance of a limb-salvage procedure in a patient with pathologic fracture, particularly for one that unites the chemotherapy, does not significantly increa se the risk of local recurrence or survival.