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[目的]研究腹腔镜手术对卵巢良性肿瘤患者机体应急反应的影响。[方法]2007年9月～2008年9月60例卵巢良性肿瘤患者随机分为腹腔镜组30例和开腹手术组30例。比较两组术前和术后1、3、5d内皮素(ET)、白细胞介素(IL-6)、C-反应蛋白(CRP)的变化。[结果]腹腔镜组术后第1dET显著下降(P<0.05),术后第3d恢复至术前水平;而开腹组手术前后ET无显著性变化。两组患者术后IL-6、CRP水平均增高(P<0.01),且开腹组显著高于腹腔镜组(P<0.01),术后第5d腹腔镜组IL-6恢复至术前水平;术后第5d两组CRP水平仍显著高于术前水平(P<0.05),且开腹组显著高于腹腔镜组(P<0.05)。[结论]腹腔镜手术对卵巢良性肿瘤患者相比开腹手术应急反应轻,强度小,持续时间短。
[Objective] To study the effect of laparoscopic surgery on the emergency response in patients with benign ovarian tumors. [Method] From September 2007 to September 2008, 60 patients with benign ovarian tumors were randomly divided into laparoscopic group of 30 cases and open group of 30 cases. The changes of endothelin (ET), interleukin (IL-6) and C-reactive protein (CRP) in the two groups were compared before and after operation. [Results] The laparoscopic group had a significant decrease (P <0.05) on the first day after operation, and returned to the preoperative level on the 3rd day after operation. There was no significant change in ET before and after laparotomy. The levels of IL-6 and CRP in both groups were significantly increased (P <0.01), and significantly higher in laparotomy group than those in laparoscopic group (P <0.01). IL-6 in laparoscopic group returned to preoperative level (P <0.05). The level of CRP in the two groups after operation was still significantly higher than that of the preoperative level (P <0.05), and the level of CRP in the open group was significantly higher than that in the laparoscopic group (P <0.05). [Conclusions] Laparoscopic surgery has the advantages of less emergency response, less intensity and shorter duration than open surgery in patients with benign ovarian tumors.