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在许多发展中国家，霍乱的发病和流行情况仍不容忽视。由于人类感染霍乱弧菌后能获得一定的免疫力，而且OI群各生物型和血清型之间有交叉免疫保护，所以有可能通过对霍乱菌苗的研究，提高机体对霍乱的兔疫保护力，以达到防治霍乱的目的。从1883年Koch发现霍乱弧菌至今，一直使
In many developing countries, the incidence and prevalence of cholera should not be overlooked. Due to human immunity after infection with Vibrio cholerae and cross-immunity between the biotypes and serogroups of the OI cohorts, it is possible to improve the body’s protection against cholera through the study of cholera vaccine In order to achieve the goal of preventing and treating cholera. From 1883 Koch Vibrio cholera has been found so far