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应用酶细胞化学技术和计算机图像分析，对豚鼠连续肌注庆大霉素（１００ｍｇ·ｋｇ－１／ｄ）２～１５ｄ后内淋巴囊上皮细胞和血管纹边缘细胞的Ｎａ＋－Ｋ＋－ＡＴＰ酶活性变化进行了定量观察。结果发现，与正常对照组相比，用药２ｄ后两类细胞的Ｎａ＋－Ｋ＋－ＡＴＰ酶活性反应产物没有明显变化，但连续用药５ｄ后二者的产物均明显减少，１０ｄ和１５ｄ仍呈继续轻微减少趋势。表明庆大霉素既可抑制血管纹边缘细胞Ｎａ＋－Ｋ＋－ＡＴＰ酶活性，降低其分泌功能；同时也能抑制内淋巴囊上皮细胞的该酶活性，减弱其液体重吸收功能。
Enzyme-linked immunosorbent assay and computer image analysis showed that Na + -K + -ATPase activity in endolymphatic sac epithelial cells and striated border cells of guinea pigs were continuously stimulated with gentamycin (100 mg · kg-1 / d) for 2 ~ 15 days The changes were quantitatively observed. The results showed that, compared with the normal control group, the products of Na + -K + -ATPase activity did not change significantly after two days of treatment, but the products of the two groups were significantly decreased after 5 days of continuous administration, and continued to be slight on the 10th and 15th days Reduce the trend. It is indicated that gentamicin can inhibit the activity of Na + -K + -ATPase in the marginal cells of the stria vascularis and decrease its secretion function, meanwhile it can also inhibit the enzyme activity of the endolymphatic sac epithelium and weaken its liquid reabsorption function.