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纤维蛋白溶酶原激动剂(PAs)将无酶活性的纤维蛋白溶酶原转变成纤维蛋白溶酶,而PAs的抑制剂(PAIs)通过与PAs形成复合物而抑制这一过程。孕妇纤溶系统最重要特性之一是血浆1型和2型PAI浓度较非孕妇增高,尽管同时测得tPA抗原浓度升高,而组织纤维蛋白溶酶原激动剂(tPA)活性下降。这些变化的结果是整个体内纤溶活性延长而凝血系统则处于高凝状态。为了解①妊娠妇女血中PAI-1和PAI-2是否有变化;②孕妇PAs/PAIs的
Plasminogen activators (PAs) convert enzymatically inactive plasminogen to plasmin, and inhibitors of PAs (PAIs) inhibit this process by forming complexes with PAs. One of the most important characteristics of the fibrinolytic system in pregnant women is the increased concentrations of plasma type 1 and type 2 PAIs compared to non-pregnant women, although the tPA antigen concentration is increased while the tissue plasminogen activator (tPA) activity is decreased. The result of these changes is the prolonged fibrinolytic activity of the entire body while the coagulation system is hypercoagulable. To find out whether there is a change in PAI-1 and PAI-2 in pregnant women; ②PAs / PAIs in pregnant women