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目的对比贝那普利与硝苯地平预防原发性高血压并发阵发房颤的疗效。方法60例原发性高血压患者随机分成硝本地平组及贝那普利组各30例,随访观察6个月内的房颤发生率。结果贝那普利组患者6个月内房颤的发生率明显减少、持续时间缩短(P<0.05);6个月后的左房内径、p波最大时限明显缩小(P<0.05)。结论贝那普利能明显延缓并逆转左心房的扩大,降低P波离散度而预防阵发性心房纤颤的复发。
Objective To compare the efficacy of benazepril and nifedipine in preventing paroxysmal atrial fibrillation in patients with essential hypertension. Methods Sixty patients with essential hypertension were randomly divided into nitrendipine group and benazepril group, 30 cases each. The incidence of atrial fibrillation within 6 months was observed. Results The incidence of atrial fibrillation in benazepril group was significantly decreased and the duration was shortened (P <0.05) within 6 months. The maximum duration of left atrial diameter and p wave was significantly reduced after 6 months (P <0.05). Conclusion Behenopril can delay and reverse the enlargement of the left atrium, reduce the dispersion of P wave and prevent the recurrence of paroxysmal atrial fibrillation.