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目的探讨妊娠期血脂水平与胎儿先天性心脏病之间的关系。方法收集2013年3月至2014年6月于中山大学附属第一医院产检的孕周为24~28周的孕母54例,其中18例存在胎儿先天性心脏病,为病例组,余36例为正常对照组。病例组与对照组孕母的年龄分别为(29.06±3.11)岁、(29.03±3.90)岁,主要检测指标包括总胆固醇、三酰甘油、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、载脂蛋白以及同型半胱氨酸。结果病例组孕母低密度脂蛋白胆固醇(4.15 mmol/L vs.3.45 mmol/L,P<0.05)及载脂蛋白B(2.23 g/L vs.1.78 g/L,P<0.05)水平较对照组明显升高。相关分析提示低密度脂蛋白胆固醇(r=0.32,P=0.017)、载脂蛋白B(r=0.33,P=0.016)及同型半胱氨酸(r=0.34,P=0.011)与胎儿患先天性心脏病相关。结论病例组血清低密度脂蛋白胆固醇和载脂蛋白B水平较对照组明显升高。妊娠期血脂代谢异常可能会导致胎儿先天性心脏病的风险增加。
Objective To investigate the relationship between serum lipids and fetal congenital heart disease during pregnancy. Methods From March 2013 to June 2014, 54 pregnant women with gestational weeks of 24 to 28 weeks were enrolled in the First Affiliated Hospital of Sun Yat-sen University from March 2013 to June 2014. Among them, 18 cases had fetal congenital heart disease, of which 36 cases For the normal control group. The age of the pregnant women in the case group and the control group were (29.06 ± 3.11) years old and (29.03 ± 3.90) years old respectively. The main test indexes included total cholesterol, triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol, Protein and homocysteine. Results Compared with the control group, the levels of serum low density lipoprotein cholesterol (4.15 mmol / L vs 3.45 mmol / L, P <0.05) and apolipoprotein B (2.23 g / L vs 1.78 g / L, P < Group was significantly higher. Correlation analysis showed that the levels of LDL cholesterol (r = 0.32, P = 0.017), apolipoprotein B (r = 0.33, P = 0.016) and homocysteine Sexual heart disease related. Conclusion The levels of serum LDL-C and apolipoprotein B in the cases were significantly higher than those in the control group. Abnormal lipid metabolism during pregnancy may lead to an increased risk of fetal congenital heart disease.