The changes of neuronal activity of the zone incerta in a rodent model of Parkinson's disease

来源 :Academic Journal of Xi'an Jiaotong University | 被引量 : 0次 | 上传用户:PoolD
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Objective To study the changes in neuronal activity of the zone incerta(ZI)following the unilateral lesion of the nigrostriatal pathway.Methods Electrophysiological recordings of ZI neurons were made in normal rats and in two groups of rats at different time intervals after injection of 6-hydrodopamine(6-OHDA)into the pars compacta of substantia nigra by extracellular recording in vivo.Results The results showed a significant increase in the mean firing rate of ZI during the second and fourth weeks after 6-OHDA lesion [n=32,(3.6±2.2)Hz,P<0.001;n=35,(9.3±6.6)Hz,P<0.001,respectively] compared to that of normal rats [n=39,(9.2±5.2)Hz].However,no significant change was observed between two groups of 6-OHDA-lesioned rats.With regard to firing pattern,7.7%(3/39)of ZI neurons discharged regularly,82.1%(32/39)irregularly and 10.3%(4/39)in bursts in normal rats.During the second week after 6-OHDA lesion,the regular,irregular and bursting firing neurons recorded in the ZI were 9.4%(3/32),59.4%(19/32)and 31.3%(10/32),and during fourth week,the regular,irregular and bursting firing neurons were 14.3%(5/35),57.1%(20/35)and 28.6%(10/35),respectively.The firing pattern of the neurons in the three different groups did not change significantly.Conclusion These results suggest that the firing rate of ZI neurons in 6-OHDA-lesioned rats is increased significantly,which may contribute to the pathophysiology of Parkinson’s disease. Objective To study the changes in neuronal activity of the zone in certa (ZI) following the unilateral lesion of the nigrostriatal pathway. Methods Electrophysiological recordings of ZI neurons were made in normal rats and in two groups of rats at different time intervals after injection of 6- hydrodopamine (6-OHDA) into the pars compacta of substantia nigra by extracellular recording in vivo. Results of the results showed a significant increase in the mean firing rate of ZI during the second and fourth weeks after 6-OHDA lesion [n = 32, ( N = 35, (9.3 ± 6.6) Hz, P <0.001, respectively] compared to that of normal rats [n = 39, (9.2 ± 5.2) Hz] change was observed between two groups of 6-OHDA-lesioned rats. Regard regard to firing pattern, 7.7% (3/39) of ZI neurons discharged regularly, 82.1% (32/39) irregularly and 10.3% (4/39) in bursts in normal rats. During the second week after 6-OHDA lesion, the regular, irregular and bursting firing neurons recorded in the ZI were 9.4% (3/32), 59.4 (19/32) and 31.3% (10/32), and during the fourth week, the regular, irregular and bursting firing neurons were 14.3% (5/35), 57.1% (20/35) and 28.6% 35), respectively. The firing pattern of the neurons in the three different groups did not change significantly. Conlusion These results suggest that the firing rate of ZI neurons in 6-OHDA-lesioned rats is more significantly, which may contribute to the pathophysiology of Parkinson’s disease.
其他文献
请下载后查看,本文暂不支持在线获取查看简介。 Please download to view, this article does not support online access to view profile.
期刊
一、中国传统文化之德治思想我国传统的德治思想是在几千年的历史实践中逐步完善的,以性善论作为理论基础,以民贵君轻为主要内容,以内圣外王为作用模式,追求和贵的思想体系。
清初,随着清王朝势力的不断扩张,以及军事与政治力量的不断西进,“回回国”的名称再次进入人们的视野。整体而言,由于清政府对“回回国”的认识,多是通过其他民族获取,因而造
继续推进两化深度融合,当务之急就是要大力培育具有创新能力的龙头企业。语录“保持工业化和信息化同步推进,是实现弯道超车重要途径。” To continue to promote the deep
通俗文学作为社会意识形态之一,对社会主义核心价值观的传播起到了重要作用。通俗文学因其本身特征在传播核心价值观中有着受众广、易接受和无限制的优势。金庸武侠小说作为
商传介绍:  商传,中国社会科学院历史研究所研究员、博士生导师。中国明史学会会长。  主要学术著作有《永乐皇帝》、《明代文化史》及关于明代典章制度、经济、社会与文化等方面的论文。曾在中央电视台《百家讲坛》栏目主讲《永乐大帝》、《明太祖朱元璋》。  晚明的政治变化  晚明的政治也发生了变化,因为经济基础变了,上层建筑也会跟着改变。我们讲三个方面的内容。  (一)万历十七年  万历十七年的年初就出了一
兴趣是学生写好习作的前提,教师要设法激发学生习作兴趣。首先,注重积累,增强自信。引导学生积累材料,为习作奠定基础,增强自信心。其次,创设情境,触发激情。创设良好的氛围,
单个产品,吸引了200多个知名品牌的合作,这是网易邮箱在互联网营销领域创造的神话。网易不仅拥有一个让全行业客户青睐有加的产品,更拥有一个能将用户价值转化为营销价值的团
To investigate whether repetitive transcranial magnetic stimulation(rTMS) can improve language function in patients with refractory epilepsy,three right-handed,
说起主题公园,我们或许首先会想到迪士尼乐园。然而在欧洲,情况可能截然不同。下面就一起去欧洲最好的主题公园看看吧。1.Popeye Village,Malta马耳他大力水手村The 1980 fil