用凝胶电泳法测定羊水中乙酰胆碱酯酶(AChE)是产前诊断胎儿开放性神经管缺陷的一项重要试验,但胎儿的其他开放性异常,特别是前腹壁缺损、脐疝、腹裂畸形(gastroschisis)也会呈现阳性结果。通过扫描光密度计测定凝胶中 AChE 带与 PChE(假性胆碱酯酶)带光密度的比值,可以把胎儿开放性前腹壁缺陷与开放性神经管缺陷区别开来。 Determination of amniotic fluid acetylcholinesterase (AChE) by gel electrophoresis is an important prenatal diagnosis of fetal open neural tube defects, but other open abnormalities in the fetus, especially anterior abdominal wall defects, umbilical hernia, gastrocytopenia (gastroschisis) will also show positive results. Determining the ratio of the AChE band in the gel to the optical density of PChE (pseudo-cholinesterase) in the gel by a scanning densitometer separates the open fetal anterior abdominal wall defects from the open neural tube defects.