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目的观察盐酸纳络酮对急性脑梗死的临床疗效及安全性。方法将8家医院150例急性脑梗死患者随机分为对照组、纳络酮治疗1组和纳络酮治疗2组,并进行多中心、随机、双盲、对照研究;各组用药前后均进行神经功能缺损评分,治疗30d和3个月分别进行Barthel指数评分,并观察药物副作用。结果对于脑梗死患者急性期神经功能缺损的改善,纳络酮治疗组均优于对照组,尤以治疗2组为明显(P<0.005),而且无明显副作用;3组间治疗30d和3个月的Barthel指数比较均无显著性差异。结论纳络酮有助于脑梗死的急性期治疗,改善临床症状,而且安全性较高。
Objective To observe the clinical efficacy and safety of naloxone hydrochloride in patients with acute cerebral infarction. Methods A total of 150 patients with acute cerebral infarction in 8 hospitals were randomly divided into control group, naloxone treatment group 1 and naloxone treatment group 2, and then conducted multi-center, randomized, double-blind and control study. Before and after treatment, Neurological deficit score, 30d and 3 months treatment Barthel index score, respectively, and observe the side effects of the drug. Results For the patients with acute cerebral infarction, the improvement of neurological deficit was better in the naloxone treatment group than in the control group, especially in the treatment group 2 (P <0.005), with no obvious side effects. The treatment of 30 d and 3 Month Barthel index no significant difference. Conclusion Naloxone can help the acute phase of cerebral infarction treatment, improve clinical symptoms, and have higher safety.