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目的探讨坤泰胶囊对多囊卵巢综合征不孕卵泡质量和激素分泌的影响。方法选取2013年1月~2015年1月在该院治疗的多囊卵巢综合征患者100例为研究对象,随机分为对照组和观察组,每组各50例。对照组采用炔雌醇环丙孕酮片加枸橼酸氯米芬加注射用尿促性素治疗,观察组在对照组的基础上加用坤泰胶囊共同治疗。结果观察组患者月经恢复率、排卵率、妊娠率高于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组搏动指数(PI)、卵泡刺激素(FSH)、黄体生成素(LH)和雌二醇(E2)水平均高于对照组,阻力指数(RI)、血清睾酮(T)、空腹胰岛素水平(FINS)、瘦素(LP)和胰岛素抵抗指数(HOMA-IR)低于对照组,差异均有统计学意义(P均<0.05)。结论坤泰胶囊治疗多囊卵巢综合征能有效改善卵巢血流,提高卵泡质量,并且能改善高雄激素血症和胰岛素抵抗,提高患者的排卵率和妊娠率。
Objective To investigate the effect of Kuntai capsule on the quality and hormone secretion of infertility follicles in women with polycystic ovary syndrome. Methods 100 patients with polycystic ovary syndrome treated in our hospital from January 2013 to January 2015 were randomly divided into control group and observation group, with 50 cases in each group. The control group was treated with ethinyl estradiol cyproterone tablets and clomiphene citrate plus urotropine injection. The observation group was treated with kuntai capsule on the basis of the control group. Results The recovery rate, ovulation rate and pregnancy rate in the observation group were significantly higher than those in the control group (all P <0.05). After treatment, the indexes of PI, FSH, LH and E2 in the observation group were higher than those in the control group, and the index of RI, serum T, The levels of fasting insulin (FINS), leptin (LP) and insulin resistance index (HOMA-IR) were lower than those of the control group (all P <0.05). Conclusions Kunitai capsule treatment of polycystic ovary syndrome can effectively improve ovarian blood flow, improve follicular quality, and can improve hyperandrogenism and insulin resistance, improve the patient’s ovulation rate and pregnancy rate.