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目的:探讨乌司他丁在治疗急性中毒相关肾损伤的预防和治疗作用。方法:128例急性中毒患者随机分为治疗组和对照组,对照组进行常规治疗,治疗组在常规治疗基础上加用乌司他丁10万U每日2次静脉滴注。观察患者的临床症状改善情况,常规检测患者血清肌酐(Cr)、尿素氮(BUN)及白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平,观察2组之间急性肾损伤的发生率和对急性肾损伤的疗效。结果:治疗组中发病后24h内及72h内患者急性肾损伤发生率分别为3%和7.5%,对照组分别为11.3%和21.2%,2组比较差异有统计学意义(P<0.05);各治疗3、7d后,治疗组均较对照组肾损伤程度显著减轻(P<0.05)。结论:乌司他丁在急性中毒治疗中可以显著减少急性肾损伤的发生率,并可促进已发生急性肾损伤的好转。
Objective: To investigate the preventive and therapeutic effects of ulinastatin in the treatment of acute renal injury induced by poisoning. Methods: A total of 128 patients with acute poisoning were randomly divided into treatment group and control group. The control group was treated routinely. The treatment group received ulinastatin 100 000 U twice daily intravenously. The clinical symptoms of the patients were observed. The levels of serum creatinine (Cr), blood urea nitrogen (BUN) and interleukin-6 (IL-6) and tumor necrosis factor-α (TNF- Between the incidence of acute renal injury and the effect of acute kidney injury. Results: The incidence of acute kidney injury in the treatment group was 3% and 7.5% within 24 hours and 72 hours after the onset of illness, respectively, in the control group was 11.3% and 21.2% respectively. There was significant difference between the two groups (P <0.05). After 3 and 7 days of treatment, the renal injury of the treatment group was significantly reduced compared with the control group (P <0.05). Conclusion: Ulinastatin can significantly reduce the incidence of acute renal injury in acute poisoning and promote the improvement of acute renal injury.