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目的探讨T2DM患者甲状腺功能与纤维蛋白原(FIB)的相关性。方法选取T2DM患者502例,测定FIB、游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)和临床生化指标,采用方差分析、Spearman相关分析及多元逐步回归分析甲状腺功能与FIB的相关性。结果(1)FT3与FIB呈负相关(r=-0.331,P<0.01)。(2)甲减组FIB高于甲亢组[(3.765±1.089)vs(3.346±0.879)pmol/L,P<0.01],与正常组[(3.232±0.985)pmol/L]比较差异无统计学意义;按FIB由低到高四分位间距分组,FT3依次为(4.54±0.96),(4.47±0.81),(3.94±1.13)及(3.67±0.95)pmol/L,P0~组与P25~组均高于P75~组(P<0.01)。(3)年龄、[脂蛋白LP-(a)]、C-RP、HbA1c是FIB的独立影响因素(β=0.382,0.272,0.552,0.221;P<0.05或P<0.01);FT3与FIB呈负相关(β=-0.289,P<0.01),且与C-RP呈依赖性。结论 T2DM患者年龄、LP-(a)、C-RP、HbA1c及FT3均与FIB相关,甲状腺激素可能通过炎症机制影响FIB。
Objective To investigate the relationship between thyroid function and fibrinogen (FIB) in T2DM patients. Methods A total of 502 patients with T2DM were enrolled in this study. The FIB, FT3, FT4, TSH and clinical biochemical parameters were determined. The variance analysis, Spearman correlation analysis and multiple stepwise regression Regression analysis of the correlation between thyroid function and FIB. Results (1) FT3 was negatively correlated with FIB (r = -0.331, P <0.01). (2) The hypothyroidism group had higher FIB than hyperthyroid group [(3.765 ± 1.089) vs (3.346 ± 0.879) pmol / L, P <0.01] and no significant difference compared with normal group [(3.232 ± 0.985) pmol / L] (P <0.05). According to the FIB from low to high quartiles, FT3 was (4.54 ± 0.96), (4.47 ± 0.81), (3.94 ± 1.13) and (3.67 ± 0.95) pmol / Group were higher than P75 ~ group (P <0.01). (3) Age, lipoprotein LP- (a)], C-RP and HbA1c were independent influencing factors of FIB (β = 0.382,0.272,0.552,0.221; P <0.05 or P <0.01) Negative correlation (β = -0.289, P <0.01), and was dependent on C-RP. Conclusion Age, LP- (a), C-RP, HbA1c and FT3 in T2DM patients are all related to FIB. Thyroid hormone may affect FIB through inflammatory mechanism.