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以45名正常临产产妇为观察对象,于活跃期静注安定10mg,并以同期未用药产妇做对照,测定血浆中前列腺素I_2(PGI_2)及血栓素A_2(TXA_2)的代谢产物6-酮-前列腺素F_1α(以下简称6PG)和血栓素B_2(TXB_2)的变化,以了解安定促进产程进展与PGI_2和TXA_2的关系。结果表明,用药组血浆6PG水平明显高于对照组(P<0.01)。而TXB_2及6PG/TXB_2比值,两组间无显著差异,提示PGI_2在安定加速产程中有着重要作用。
Forty-five normal pregnant women were enrolled in this study. In the active phase, 10 mg of diazepam was given intravenously and compared with the untreated mothers during the same period. The levels of plasma PG-2 and TXA-2 metabolites, 6-keto- Prostaglandin F_1α (hereinafter referred to as 6PG) and thromboxane B_2 (TXB_2) changes in order to understand the stability of the labor process and PGI_2 and TXA_2 relationship. The results showed that the plasma 6PG level in the treatment group was significantly higher than that in the control group (P <0.01). The ratio of TXB_2 and 6PG / TXB_2 showed no significant difference between the two groups, suggesting that PGI_2 plays an important role in the stabilization of labor.