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宫颈癌是一种严重危害女性健康的恶性肿瘤,其发病率位居女性恶性肿瘤的第2位[1]。自德国医学家Harald zur Hausen 20世纪70年代提出人乳头瘤病毒(human papillomavirus,HPV)可能导致宫颈癌,至今已有大量流行病学和分子生物学研究证实[2-11]:高危型HPV持续感染促使宫颈细胞发生恶性转化,并维持细胞恶性表型的持续表达,是宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)及宫颈癌发生、发展的首要病因。
Cervical cancer is a malignant tumor that seriously endangers women’s health. The incidence of cervical cancer ranks the second among women with malignant tumors [1]. Since the German medical scientist Harald zur Hausen proposed the human papillomavirus (HPV) in the 1970s to cause cervical cancer, so far a large number of epidemiological and molecular biological studies have been confirmed [2-11]: high-risk HPV lasts Infection causes malignant transformation of cervical cells and sustained expression of malignant phenotype of the cells, which is the primary cause of the development of cervical intraepithelial neoplasia (CIN) and cervical cancer.