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目的观察四逆散加减方醇提物体内抗鸭乙型肝炎病毒(DHBV)的作用。方法采用先天感染鸭乙型肝炎病毒的广州麻鸭为动物模型,检测用药前后鸭血清DHBV-DNAOD值的变化,并以阿昔洛韦作阳性对照。结果停用后第3天,四逆散原方组鸭血清DHBV-DNAOD值明显低于用药前(P<0.05);用药后第5天和第10天,四逆散加味组鸭血清DHBV-DNAOD值明显低于用药前(P<0.05,P<0.01);用药后第10天,四逆散加味组的中位抑制率与对照组比较有显著性差异(P<0.05)。结论四逆散原方、四逆散加味方在鸭体内有抗乙型肝炎病毒作用。
Objective To observe the anti-duck hepatitis B virus (DHBV) effect in Sinisan plus alcohol extracts. Methods The Guangzhou duck was congenitally infected with duck hepatitis B virus. The animal model was used to detect the change of duck serum DHBV-DNA OD before and after treatment. Acyclovir was used as a positive control. On the 3rd day after discontinuation, the DHBV-DNA OD value of duck serum in the Sinisan group was significantly lower than before treatment (P<0.05); on the 5th and 10th days after the administration, the serum of the SHBV powder group DHBV- The DNAOD value was significantly lower than before treatment (P<0.05, P<0.01). On the 10th day after administration, the median inhibition rate of Sini San flavored group was significantly different from that of the control group (P<0.05). Conclusion Sinisanfang and Sini Powder have anti-hepatitis B virus effect in ducks.