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本文证明硝硫氰胺(C 9333-(Go/CGP 4540)类的衍生物4-硝基二苯胺-4′-硫代氨基甲酸(O)苯酯(代号7720)有与硝硫氰胺同等强度的抗血吸虫作用。用粗粉混悬液灌胃治疗小白鼠实验性血吸虫病,7720和硝硫氰胺的CD_(50)分别为79.0μmol/kg/d(即28.8mg/kg/d)×5日和83.4μ mol/kg/d(即22.6mg/kg/d)×5日。7720 16或32 mg/kg/d×5d已可使所试全部病免达寄生虫学治愈。未能测出小白鼠灌胃急性LD_(50)。通过对幼年大白鼠体重增长影响的观察,家犬亚急性毒性试验及内脏组织病理学检查等提示本药经口给药无严重毒性反应。本文还证明4-硝基-4′-异硫氰基二苯醚对家兔实验性血吸虫病亦有较佳疗效。
This paper demonstrates that the derivative of 4 9-nitrodiphenylamine-4’-thiocarbamate (codenamed 7720), a derivative of C 9333- (Go / CGP 4540), is equivalent to nitrosated cyanamide Strength of anti-schistosomiasis treatment of experimental mice schistosomiasis with coarse powder suspension ganoderma, 7720 and nitrite thiocyanate CD_ (50) were 79.0μmol / kg / d (ie, 28.8mg / kg / d) × 5 days and 83.4 μmol / kg / d (ie 22.6 mg / kg / d) × 5 days .7720 16 or 32 mg / kg / d × 5d had all the disease tested parasite parasitic cure. The acute LD 50 could be measured in mice by intragastric administration, and the subacute toxicity test and visceral histopathological examination in domestic dogs suggest that the oral administration of this medicine has no serious toxicity. It has also been demonstrated that 4-nitro-4’-isothiocyanatodiphenyl ether also has a better therapeutic effect on experimental schistosomiasis in rabbits.