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本研究对６８例氯丁二烯（ＣＢＤ）接触工人和４９例健康人进行了调查。结果显示，ＣＢＤ接触组血清中甘胆酸（ＣＧ）含量明显升高，而血清中丙氨酸转氨酶、硫酸锌浊度试验和麝香草酚浊度试验无明显改变；全血谷胱甘肽过氧化物酶（ＧＳＨ—Ｐｘ）活性和血清铜蓝蛋白（ＣＰ）含量明显降低，这与动物实验结果基本一致，即ＣＢＤ在体内生成的活性中间物可导致氧化性损害。血清ＣＧ含量、全血ＧＳＨ—ｐｘ活性及血清ＣＰ可能是接触ＣＢＤ所致不良健康效应的生物标记。
In this study, 68 cases of workers exposed to chlorbutadiene (CBD) and 49 healthy people were investigated. The results showed that the content of glycocholic acid (CG) in serum of CBD exposure group was significantly increased, while the serum alanine aminotransferase, zinc sulfate turbidity test and thymol turbidity test did not change significantly; whole blood glutathione Oxidase (GSH-Px) activity and serum ceruloplasmin (CP) content decreased significantly, which is consistent with the results of animal experiments, that is, the active intermediate produced by CBD in vivo can lead to oxidative damage. Serum CG levels, whole blood GSH-px activity, and serum CP may be biomarkers of adverse health effects from exposure to CBD.