论文部分内容阅读
目的:探讨乳腺癌组织BRCA1与FANCD2基因表达,明确BRCA1基因与FANCD2基因之间的相关性。方法:选取104例乳腺癌手术标本,其中家族性乳腺癌52例,散发性乳腺癌52例。采用SP免疫组化法检测BRCA1和FANCD2在家族和散发性乳腺癌组织中的表达。结果:在家族性乳腺癌组织中,BRCA1蛋白阳性表达37例(71.2%),FANCD2蛋白阳性表达18例(34.6%),两组差异有统计学意义,P<0.05。在散发性乳腺癌组织中,BRCA1蛋白阳性表达19例(36.5%),FANCD2蛋白阳性表达27例(51.9%),两组差异无统计学意义。结论:BRCA1和FANCD2基因表达与乳腺癌的发生和发展存在一定相关性,FANCONI/BRCA通路的抑制,可能是乳腺癌,尤其是家族性乳腺癌发生发展以及形成的原因之一。
Objective: To investigate the expression of BRCA1 and FANCD2 genes in breast cancer and to clarify the correlation between BRCA1 gene and FANCD2 gene. Methods: 104 cases of breast cancer were selected, including 52 cases of familial breast cancer and 52 cases of sporadic breast cancer. SP immunohistochemistry was used to detect the expression of BRCA1 and FANCD2 in familial and sporadic breast cancer tissues. Results: The positive expression of BRCA1 protein in familial breast cancer tissues was 37 (71.2%) and that of FANCD2 protein was 18 (34.6%). There was significant difference between the two groups (P <0.05). In sporadic breast cancer, BRCA1 protein expression was positive in 19 cases (36.5%), FANCD2 protein expression was 27 cases (51.9%), there was no significant difference between the two groups. Conclusion: The expression of BRCA1 and FANCD2 may be related to the occurrence and development of breast cancer. The inhibition of FANCONI / BRCA pathway may be one of the reasons for the development and formation of breast cancer, especially familial breast cancer.