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目的研究了晕痛定泡腾片的工艺制备过程,确定最佳成型工艺。方法采用正交试验,对晕痛定泡腾片成型工艺进行考察,并以外观、休止角、口感和崩解时限为指标综合评价,以总评分确定成型工艺条件。结果确定每1个处方填充剂(柠檬酸:碳酸氢钠:乳糖)最佳配比为0.85∶1∶1.15,主药与填料配比为1∶1.5,加1.5%硬脂酸镁做润滑剂。结论本试验采用的工艺和成型方法适合于晕痛定泡腾片的制备。
Objective To study the preparation process of Halo tablet for effervescent tablets and determine the best forming process. Methods The orthogonal test was used to investigate the forming process of Haliotisdione effervescent tablets. The appearance, angle of repose, mouthfeel and disintegration time were used as indexes to evaluate the forming process conditions. The results showed that the best proportion of each prescription filler (citric acid: sodium bicarbonate: lactose) was 0.85:1:1.15, the ratio of main drug to filler was 1: 1.5, and 1.5% magnesium stearate as lubricant . Conclusion The process and method used in this study are suitable for the preparation of Haliotisditis effervescent tablets.