论文部分内容阅读
本文报道蒿甲醚在兔体内的药代动力学。静脉输注蒿甲醚脂肪乳剂(蒿甲醚80mg/kg)后,血药时间数据用NONLIN程序拟合曲线,符合线性二室开模型。药代动力学参数的平均(SD)为:t1/2(α和β)分别为0.144(0.077)h和0.896(0.371)h;k_(2t),k_(10)和k_(12)分别为1.235(0.705),4.143(1.370)和1.140(0.951)h~(-1);V_c,V_d(area)和V_(d(ss))分别为0.609(0.119),2.985(0.787)和1.054(0.202)L/kg;清除率为2.401(0.339)L·kg~(-1)·h。 肌内注射油剂250mg/kg或125mg/kg,血药时间数据按矩量法计算,得吸收速率常数(Ka)为0.0377(0.0119)h~(-1);吸收程度为36.14(18.39)%。
This article reports the pharmacokinetics of artemether in rabbits. Intravenous infusion of artemether fat emulsion (Artemether 80mg / kg), blood drug data using NONLIN program fitting curve, in line with the linear two-compartment open model. The mean (SD) pharmacokinetic parameters were: t1 / 2 (α and β) were 0.144 (0.077) h and 0.896 (0.371) h, respectively; k 2t, k 10 and k 12 were V_c, V_d (area) and V_ (d (ss)) were 0.609 (0.119), 2.985 (0.787) and 1.054 (0.202 ) L / kg; clearance rate was 2.401 (0.339) L · kg -1 (-1) h. Intramuscular injection of 250mg / kg or 125mg / kg, blood drug time data by the moment method, the absorption rate constant (Ka) was 0.0377 (0.0119) h ~ (-1); degree of absorption was 36.14 (18.39)%, .